業績ACHIVEMENT

2016年～現在

研究論文

• Microbial production of aromatic compounds and synthesis of high-performance bioplastics. Masuo, Shunsuke, Bioscience, biotechnology, and biochemistry Epub 2024年8月

• Efficient encapsulation of Hinoki essential oil with β-cyclodextrin using an ultrasound-aided coprecipitation technique for dual anti-Listeria monocytogenes and anti-Staphylococcus aureus activities. Kong, Peifu, Zulfikar, Ainun, Thangunpai, Kotchaporn, Masuo, Shunsuke, Abe, Junichi P., Enomae, Toshiharu. International Journal of Biological Macromolecules 270(1) 2024年5月

• The Metabolic Regulation of Amino Acid Synthesis Counteracts Reactive Nitrogen Stress via Aspergillus nidulans Cross-Pathway Control. Madoka Amahisa, Madoka Tsukagoshi, Chihiro Kadooka, Shunsuke Masuo, Norio Takeshita, Yuki Doi, Hiroshi Takagi, Naoki Takaya, Journal of fungi (Basel, Switzerland) 10(1) 2024年1月10日

• Fungal glyceraldehyde 3-phosphate dehydrogenase GpdC maintains glycolytic mechanism against reactive nitrogen stress-induced damage. Chihiro Kadooka, Nozomi Katsuki, Shunsuke Masuo, Saito Kojima, Madoka Amahisa, Kouta Suzuki, Yuki Doi, Norio Takeshita, Naoki Takaya, Frontiers in microbiology 15 1475567-1475567 2024年

• Protocatechuate hydroxylase is a novel group A flavoprotein monooxygenase with a unique substrate recognition mechanism. Katsuki, Nozomi, Fukushima, Riku, Doi, Yuki, Masuo, Shunsuke, Arakawa, Takatoshi, Yamada, Chihaya, Fushinobu, Shinya, Takaya, Naoki, The Journal of biological chemistry 300(1) 2024年1月

• Genes encoding a novel thermostable bacteriocin in the thermophilic bacterium Aeribacillus pallidus PI8. Kita, Kyosuke, Yoshida, Sanako, Masuo, Shunsuke, Nakamura, Akira, Ishikawa, Shu, Yoshida, Ken-Ichi, JOURNAL OF APPLIED MICROBIOLOGY 134(12) 2023年12月

• Preparation and characterization of tea tree oil-β-cyclodextrin microcapsules with super-high encapsulation efficiency. Kong, Peifu, Abe, Junichi Peter, Masuo, Shunsuke, Enomae, Toshiharu, JOURNAL OF BIORESOURCES AND BIOPRODUCTS 8(3) 224-234 2023年8月

• Preparation of Green Anti-Staphylococcus aureus Inclusion Complexes Containing Hinoki Essential Oil. Kong, Peifu, Thangunpai, Kotchaporn, Zulfikar, Ainun, Masuo, Shunsuke, Abe, Junichi Peter, Enomae, Toshiharu, FOODS 12(16) 2023年8月

• Gallic acid fermentation by metabolically engineered Escherichia coli producing p-hydroxybenzoate hydroxylase from Hylemonella gracilis NS1. Katsuki, Nozomi, Masuo, Shunsuke, Nukui, Noriyuki, Minakawa, Hajime, Takaya, Naoki, JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY 69(6) 301-308 2023年8月

• Local calcium signal transmission in mycelial network exhibits decentralized stress responses. Itani, Ayaka, Masuo, Shunsuke, Yamamoto, Riho, Serizawa, Tomoko, Fukasawa, Yu, Takaya, Naoki, Toyota, Masatsugu, Betsuyaku, Shigeyuki, Takeshita, Norio, PNAS nexus 2(3) pgad012 2023年3月

• Machine learning-assisted medium optimization revealed the discriminated strategies for improved production of the foreign and native metabolites. AIDA, Honoka, UCHIDA, Keisuke, NAGAI, Motoki, HASHIZUME, Takamasa, MASUO, Shunsuke, TAKAYA, Naoki, YING, BEIWEN, COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 21 2654-2663 2023年2月

• Metabolic engineering for 4-aminophenylalanine production from lignocellulosic biomass by recombinant Escherichia coli. Hideo Kawaguchi, Shunsuke Masuo, Keiko Wakai, Naoki Takaya, Tomohisa Hasunma, Tatsuo Kaneko, Satoshi Okada, Takashi Sazuka, Chiaki Ogino, Akihiko Kondo, RSC Sustainability 2023年

• Translocation of acibenzolar, an active metabolic substance of acibenzolar-S-methyl, to distal leaves in cabbage and Japanese radish. Sakata, Nanami, Masuo, Shunsuke, Nagayoshi, Rino, Ishiga, Takako, Ishiga, Yasuhiro, JOURNAL OF GENERAL PLANT PATHOLOGY 88(6) 392-398 2022年11月

• Microbial pyrazine diamine is a novel electrolyte additive that shields high-voltage LiNi1/3Co1/3Mn1/3O2 cathodes. Gupta, Agman, Badam, Rajashekar, Takamori, Noriyuki, Minakawa, Hajime, Masuo, Shunsuke, Takaya, Naoki, Matsumi, Noriyoshi, Scientific reports 12(1) 2022年11月

• Carboxypeptidase G and pterin deaminase metabolic pathways degrade folic acid in Variovorax sp. F1. You, Yungmi, Doi, Yuki, Maeda, Norifumi, Masuo, Shunsuke, Takeshita, Norio, Takaya, Naoki, BMC microbiology 22(1) 225 2022年9月

• Fermentative production of 2-(4-aminophenyl)ethylamine to synthesize a novel heat-resistant biopolyurea. Minakawa, Hajime, Masuo, Shunsuke, Takada, Kenji, Kumakura, Takuya, Katsuki, Nozomi, Kaneko, Tatsuo, Takaya, Naoki, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 86(8) 1114-1121 2022年7月

• Pseudomonas cannabina pv. alisalensis Virulence Factors Are Involved in Resistance to Plant-Derived Antimicrobials during Infection. Sakata, Nanami, Haraguchi, Takumi, Masuo, Shunsuke, Ishiga, Takako, Ishiga, Yasuhiro, PLANTS-BASEL 11(13) 2022年6月

• Glucose-Derived Raspberry Ketone Produced via Engineered Escherichia coli Metabolism. Masuo, Shunsuke, Saga, Chisa, Usui, Kurumi, Sasakura, Yuma, Kawasaki, Yukie, Takaya, Naoki, Frontiers in bioengineering and biotechnology 10 2022年2月

• Coronatine contributes to pv. virulence by overcoming both stomatal and apoplastic defenses in dicot and monocot plants. Sakata, Nanami, Ishiga, Takako, Masuo, Shunsuke, Hashimoto, Yoshiteru, Ishiga, Yasuhiro, Molecular plant-microbe interactions : MPMI 34(7) 746-757 2021年2月

  総説

  • 老沼研一、高谷直樹：ヒドラジン類縁化合物の微生物代謝―明らかとなった新規分解機構、化学と生物
  • 桝尾俊介、土肥裕希、高谷直樹：酸化ストレスに強いカビと細菌のストレス耐性機構、生物工学会誌2015年8号、457-459 (2015)
  • 金子達雄、高谷直樹：セ氏425度という高温に耐えられるバイオプラスチックを開発―微生物と光化学反応によるポリイミド合成、化学と生物、53、270-272 (2015)
  • 周勝敏、高谷直樹：ニトロソチオネインの発見と真菌の一酸化窒素耐性化、バイオサイエンスとインダストリー、72, 132-133 (2014)
  • 桝尾俊介、老沼研一、高谷直樹: 多様な微生物代謝を利用した芳香族バイオ素材の開発、ケミカルエンジニヤリング(2013)
  • Takaya, N.: Response to hypoxia, reduction of electron acceptors, and subsequent survival by filamentous fungi,Biosci. Biotech. Biochem.73, 1-8 (2009)
  • 安部剛史、高谷直樹：カビによる新規な異化代謝の機能解明とその利用の可能性、J. Environmental Biotechnology.6, 79-85 (2007)
  • 高谷直樹、志水元亨：息づまる闘い－カビの生き残り戦略？、生物工学会誌、85、416 (2007)
  • 高谷直樹、祥雲弘文：低酸素環境下でのカビの呼吸と発酵、バイオサイエンスとインダストリー、63、233-236 (2005)佐々木康幸、高谷直樹、祥雲弘文：廃水からの窒素除去システムの現状と展望、生物工学会誌、83、202 (2005)
  • 高谷直樹、祥雲弘文：低酸素状態でのカビの生き残り戦略―わかってきたカビ脱窒系の役割。呼吸系の進化や窒素サイクルを考えるヒントに、化学と生物、40巻，356-358 (2002)
  • Takaya, N.: Dissimilatory nitrate reduction metabolisms and their control in fungi, J. Biosci. Bioeng. 94, 506-510 (2002)
  • Zhou, Z., Takaya, N., and Shoun, H.: Denitrification by eukaryotic microorganisms, Recent Research Developments in Microbiology, vol. 6, 259-268, Research Signpost, Kerala, India (2002)
  • Takaya, N., Horiuchi, H., and Takagi, M.: 糸状菌による異種蛋白質生産の現状と展望, 食品工業 37巻, 16-21 (1994).
    

    著書

    • 大腸菌への人工生合成経路の導入によるラズベリーケトン生産桝尾 俊介; 薄井くるみ; 高谷直樹,  B&I バイオサイエンスとインダストリー/（一財）バイオインダストリー協会, 2023-09-10
    • Zhang, L., Kudo, T., Takaya, N., and Shoun, H.: Distribution, structure and function of fungal nitric oxide reductase P450nor-recent advances, in Excerpta Medica International Congress Series vol. 1233, p197-202, Y. Ishimura, M. Nozaki, S. Yamamoto, T. Shimizu, S. Narumiya, and F. Mitani,. Eds., Elsevier, Amsterdam, The Netherlands (2002).
    • Shoun H., and Takaya, N.: Cytochrome P450nor and P450foxy from the fungus Fusarium oxysporum, in Excerpta Medica International Congress Series vol. 1233, p89-97, Y. Ishimura, M. Nozaki, S. Yamamoto, T. Shimizu, S. Narumiya, and F. Mitani,. Eds., Elsevier, Amsterdam, The Netherlands (2002).
    • Kitazume, T., Tanaka, A., Matsuyama, S., Takaya, N. and Shoun, H.: Analysis of fungal P450foxy (CYP505), a fused protein of cytochrome P450 and its reductase. in Excerpta Medica International Congress Series vol. 1233, p143-149, Y. Ishimura, M. Nozaki, S. Yamamoto, T. Shimizu, S. Narumiya, and F. Mitani,. Eds., Elsevier, Amsterdam, The Netherlands (2002).
    • Takaya, N., Kobayashi, M., and Shoun, H.: Fungal denitrification, possible occurrence of a natural horizontal gene transfer from prokaryote to eukaryote. in ‘Proceedings of Fallen Leaf Conference on Horizontal Gene Transfer: Implications and Consequences’ eds. M. Syvanen and C. Kado, Chapsman & Hall, p321-327 (1998).
    • Takaya, N., Kudo, T., and Shoun, H.: Analysis of NAD(P)H binding site of cytochrome P450nor. in ‘Oxygen homeostasis and its dynamics’ Ishimura, Ed., Springer-Verlag Tokyo, Tokyo, Japan. p163-167 (1997).

  受賞

  • 優秀発表賞：酒造ひなた
    マイクロ流体デバイスで示す外部環境に応じた糸状菌の伸長方向制御
    日本農芸化学会関東支部大会（2024年8月）、東京
  • 学生優秀発表賞：野村結南
    根圏合成コミュニティにおいて根粒共生を促進する微生物の解析
    第33回植物微生物研究会（2024年8月）、オンライン
  • 合同酒精特別賞：井谷綾花
    麹菌における核の増加と菌糸形態および酵素生産性の関連
    第22回糸状菌分子生物学コンファレンス（2023年11月）、徳島
  • 微生物インダストリー賞：戸田征宏
    細菌-糸状菌間相互作用におけるトランスクリプトームの比較解析
    第22回糸状菌分子生物学コンファレンス（2023年11月）、徳島
  • ポスター発表賞：頼永萌々佳
    3rd Plant Microbiota Research Network (PMRN) 2023（2023年9月）、オンライン
  • 優秀発表賞：酒造ひなた
    植物病原性⽷状菌 Fusarium oxysporum の侵襲性と病原性の関連
  • 優秀発表賞：⼾⽥征宏
    日本微生物生態学会第35回札幌大会（2022年11月）、札幌日本農芸化学会関東支部大会（2023年8月）、東京
  • Best presentation award：Gayan Abeysinghe
    細菌-⽷状菌間相互作⽤におけるトランスクリプトームの⽐較解析
    日本農芸化学会関東支部大会（2023年8月）、東京
  • ポスター賞受賞：天久まどか
    アミノ酸生合成を介した Aspergillus nidulans の一酸化窒素ストレス耐性機構
    第21回糸状菌分子生物学コンファレンス（2022年11月）、オンライン
  • ポスター賞受賞：酒造ひなた
    植物病原性⽷状菌 Fusarium oxysporum の侵襲性と病原性の関連
    第２１回糸状菌分子生物学コンファレンス（2022年11月）、オンライン
  • 合同酒精特別賞：一ノ瀬恵
    麹菌における核の増加と菌糸形態および酵素生産性の関連
    第21回糸状菌分子生物学コンファレンス（2022年11月）、オンライン
  • 優秀発表賞：前田典歩
    Cupriavidus sp. LA-1株によるルマジン分解機構の解明
    日本農芸化学会関東支部大会（2022年8月）、オンライン
  • ポスター賞受賞：山本里穂
    マイクロ流体デバイスで示す外部環境に応じた糸状菌の伸長方向制御
    第20回糸状菌分子生物学コンファレンス（2021年11月）、オンライン
  • 合同酒精特別賞：西岡利隆
    芳香族主鎖型ポリマー加水分解酵素の探索と機能解析
    第20回糸状菌分子生物学コンファレンス（2021年11月）、オンライン
  • 優秀発表賞：前田典歩
    細菌によるルマジン分解機構の解明
    日本農芸化学会関東支部大会（2021年8月）、オンライン
  • 学生優秀発表賞：山本里穂
    マイクロ流体デバイスを用いた糸状菌の菌糸における可変性の解析
    糸状菌分子生物学研究会若手の会（2020年11月）、オンライン
  • 優秀発表企業賞（月桂冠うるおい賞）：細田柊志
    麹菌における核増加の分子機構
    糸状菌分子生物学研究会若手の会（2020年11月）、オンライン
  • Best Poster Award：Gayan Dakshitha
    15th European Conference on Fungal Genetics（2020年2月）、Rome, Italy
  • ポスター賞受賞：福田紗弓
    マイクロ流体デバイスを用いた糸状菌の菌糸の屈性と可塑性の解析
    第18回糸状菌分子生物学コンファレンス（平成30年11月）、長岡
  • 微生物インダストリー賞：安井瑞稀
    米麹におけるコウジカビの破精込みの蛍光イメージング解析
    第18回糸状菌分子生物学コンファレンス（平成30年11月）、長岡
  • Best Poster Award：Gayan Dakshitha and Sayumi Fukuda
    TGSW2018（2018年9月）、Tsukuba
  • Excellent Poster Award：Tomoko Serizawa
    TGSW2018（2018年9月）、Tsukuba
  • Excellent Poster Award：Momoka Kuchira
    Gram-positive bacterium genome function conference（2018年9月）、Atami
  • ポスター賞受賞：久知良桃花
    糸状菌の菌糸を足場にした枯草菌の生育様式の解析
    第16回微生物研究会（平成29年11月）、東京
  • 優秀発表賞：金澤拓史
    環境中のビタミン恒常性を担う複合微生物系
    日本農芸化学会関東支部大会（平成29年9月）、つくば
  • 若手奨励賞：伊藤英里子
    Sirtuin Eは糸状菌の対数期から定常期への転写の移行をグローバルに制御する
    日本農芸化学会関東支部大会（平成28年9月）、東京
  • ポスター賞受賞：茂本亮輔
    Sirtuin 活性の制御による糸状菌の休眠二次代謝系遺伝子の活性化
    第15回糸状菌分子生物学コンファレンス（平成27年11月）、東京
  • 若手奨励賞：塚越まどか
    糸状菌 Aspergillus nidulans のアミノ酸生合成制御を介した NO 耐性機構
    日本農芸化学会関東支部大会（平成27年9月）、東京
  • 若手口頭発表部門優秀発表賞：金澤拓史, 柳榮美, 高谷直樹
    環境中のビタミン恒常性を担う複合微生物系
    日本農芸化学会関東支部大会(平成27年9月)、つくば
  • ポスター賞受賞：阿部央行，桝尾俊介，高谷直樹
    Aspergillus nidulans の低酸素誘導性脱ユビキチン化酵素の機能
    第14回糸状菌分子生物学コンファレンス（平成26年11月)、仙台
  • ポスター賞受賞：中澤奈美，老沼研一，高谷直樹
    糸状菌 Aspergillus nidulans による土壌フミン酸の代謝機構
    第13回糸状菌分子生物学コンファレンス（平成25年11月)、つくば
  • ポスター賞受賞：伊藤英里子、志水元亨、桝尾俊介、高谷直樹
    Aspergillus nidulans の sirtuin 様タンパク質 SirA の機能解析
    第12回糸状菌分子生物学コンファレンス（平成24年11月)、名古屋
  • 若手奨励賞：上村曜介、鳴神寿昭、桝尾俊介、高谷直樹
    糸状菌 Aspergillus nidulans の二次代謝産物生合成における転写因子AmyRの役割
    日本農芸化学会関東支部大会(平成23年10月)、群馬
  • ポスター賞受賞：上村曜介、鳴神寿昭、桝尾俊介、高谷直樹
    転写因子AmyRが Aspergillus nidulans の二次代謝に及ぼす影響の解析
    第10回糸状菌分子生物学コンファレンス（平成22年11月)、広島
  • 日本醸造学会若手の会ポスター賞受賞：上村曜介、鳴神寿昭、桝尾俊介、高谷直樹
    転写因子AmyRが Aspergillus nidulans の二次代謝に及ぼす影響の解析
    日本醸造学会若手の会（平成22年9月）、東京
  • 第21回日本微生物生態学会大会優秀ポスター発表賞：豊福雅典・野村暢彦・高谷直樹・藤井達也・中島敏明・内山裕夫
    Pseudomonas aeruginosa における細胞間情報伝達シグナルの脱窒への関与（2005年11月）

2020年以前の論文

• Nakai, R., Kusada, H., Sassa, F., Morigasaki, S., Hayashi, H., Takaya, N., Tamaki, H.: Genomic insights into a novel filterable Rhodospirillales bacterium strain TMPK1 isolated from soil. (MRA00393-21)
• A.Nag., M.A.Ali., H.Kawaguchi., S.Saito., Y.Kawasaki., S.Miyazaki., H.Kawamoto., D.T.N.Adi., K.Yoshihara., S.Masuo., Y.Katsuyama., A.Kondo., C.Ogino., N.Takaya., T.Kaneko., Y.Ohnishi.,: Ultrahigh Thermoresistant Lightweight Bioplastics Developed from Fermentation Products of Cellulosic Feedstock. Adv. Sus. Sys., 5, 2000193 (2020)
• Kanazawa, H., Ozaki, S., Doi, Y., Masuo, M., Takaya, N.: Symbiotic riboflavin degradation by Microbacterium and Nocardioides bacteria. Biosci. Biotechnol. Biochem. 84, 1056-1061 (2020)
• Masuo, S., Tsuda, Y., Namai,T., Minakawa, H., Shigemoto, R., Takaya, N.: Enzymatic cascade in Pseudomonas for pyrazine production from α-amino acids. ChemBioChem, 21, 353-359 (2020)
• Yang, Y., Zhou, Y., Li, J., Yu, H., Takaya, N., Wang, P., Zhou, S.: Novel peroxiredoxin-based sensor for sensitive detection of hydrogen peroxide. Biochem Biophys Res Commun. (2019)
• H, Kawaguchi., H, Miyagawa., S, Nakamura-Tsuruta., N, Takaya., C, Ogino., A, Kondo.: Enhanced phenyllactic acid production in Escherichia coli via oxygen limitation and shikimate pathway gene expression. Biotechnology Journal, 14, e1800478 (2019)
• Minakawa, H., Masuo, S., Kaneko, T., Takaya, N.: Fermentation and purification of the microbial monomer 4-amminocinnamic acid for producing ultra-high performance plastics. Process Biochem. 77, 100-105 (2019)
• Sakai, K., Matsuzaki, F., Wise, L., Sakai, T., Jindou, S., Ichinose, H., Takaya, N., Kato, M., Wariishi, H., and Shimizu, M.: Biochemical characterization of CYP505D6, a self-sufficient cytochrome P450 from the white-rot fungus Phanerochaete chrysosporium. Appl. Environ. Microbiol., 84, e01091-01118
• Kanazawa, H., Shigemoto, R., Kawasaki, Y., Oinuma, K.-I., Nakamura, A., Masuo, S., Takaya, N.: Two-component flavin-dependent riboflavin monooxygenase degrades riboflavin in Devosia riboflavina. J. Bacteriol., 200, e00022-18 (2018)
• Shigemoto, R., Matsumoto, T., Masuo, S., Takaya, N.: 5-Methylmellein is a novel inhibitor of fungal sirtuin and modulates fungal secondary metabolite production. J. Gen. Appl. Micorbiol.,64, 240-247 (2018)
• Oinuma, K.-I., Yamaguchi, I., Shindo, D., Fujimoto, M., Nishiyama, T., Takano, H., Takaya, N., Ueda, K.: Extracytoplasmic diaphorase activity of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun. 10;503(3): 1581-1586 (2018)
• Shigemoto, R., Oinuma, K.-I., Masuo, S., Takaya, N.: Novel antioxidant isolated from Warcupiella spinulosa JCM 2358, 7-hydroxycordylactam. Heterocycles, 96, 1075-1079 (2018)
• Masuo, S., Komatsuzaki, A., Takeshita, N., Ito, E., Okazoe, Zhou, S., Takaya, N.: Heterogeneous localization of glycogen and its metabolizing enzymes in Aspergillus nidulans hyphae. Fungal Genet. Biol. 110, 48-55 (2018)
• Kawasaki, Y., Aniruddha, N., Minakawa, H., Masuo, S., Kaneko, K., Takaya, N.: Novel poly-condensed biopolyamide generated from biomass-derived 4-aminohydrocinnamic acid. Appl. Microbiol. Biotechnol. 108, 631-639 (2018)
• Xia, Y., Yu, H., Zhou, Z., Takaya, N., Zhou, S., Wang, P.: Peroxiredoxin system of Aspergillus nidulans resists inactivation by high concentration of hydrogen peroxide-mediated oxidative stress. J. Microbiol. Biotechnol., 28, 145-156 (2018)
• Takeshita, N., Evangelinos, M., Zhou, L., Serizawa, T., Somera-Fajardo, R. A., Lu, L., Takaya, N., Nienhaus, G. U., and Fischer, R.: Pulses of Ca²⁺ coordinate actin assembly and exocytosis for stepwise cell extension. Proc. Natl. Acad. Sci. USA, 114, 5701-5706 (2017)
• Itoh, E., Odakura, R., Oinuma, K.-I., Shimizu, M., Masuo, S., Takaya, N.: Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase. J. Biol. Chem. 292, 11043-11054 (2017)
• Akiyama, T., Ishii, M., Takuwa, A., Oinuma, K.-I., Sasaki, Y., Takaya, N., Yajima, S.: Structural basis of the substrate recognition of hydrazidase isolated from Microbacterium sp. strain HM58-2, which catalyzes acylhydrazide compounds as its sole carbon source. Biochem Biophys Res Commun. 482, 1007-1012 (2017)
• Itoh, E., Shigemoto, R., Oinuma, K.-I., Shimizu, M., Masuo, S., Takaya, N.: Sirtuin A regulates secondary metabolite production by Aspergillus nidulans. J. Gen. Appl. Micorbiol., 63, 228-235 (2017)
• Akiyama, T., Yamada, Y., Takaya, N., Ito, S., Sasaki, Y., Yajima, S.: Crystal structure of an IclR homologue from Microbacterium sp. strain HM58-2. Acta Crystallogr F Struct Biol Commun. 73, 16-23 (2017)
• Takeshita, N., Evangelinos, M., Zhou, L., Serizawa, T., Somera-Fajardo, R. A., Lu, L., Takaya, N., Nienhaus, G. U., and Fischer, R.: Pulses of Ca²⁺ coordinate actin assembly and exocytosis for stepwise cell extension. Proc. Natl. Acad. Sci. USA, (in press, 2017)
• Itoh, E., Odakura, R., Oinuma, K.-I., Shimizu, M., Masuo, S., and Takaya, N.: Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase. J. Biol. Chem. (in press, 2017)
• Akiyama T, Ishii M, Takuwa A, Oinuma KI, Sasaki Y, Takaya N, Yajima S.: Structural basis of the substrate recognition of hydrazidase isolated from Microbacterium sp. strain HM58-2, which catalyzes acylhydrazide compounds as its sole carbon source. Biochem Biophys Res Commun. 482, 1007-1012 (2017)
• Itoh, E., Shigemoto, R., Oinuma, K.-I., Shimizu, M., Masuo, S., and Takaya, N.: Sirtuin A regulates secondary metabolite production byAspergillus nidulans. J. Gen. Appl. Micorbiol. (in press, 2017)
• Akiyama T, Yamada Y, Takaya N, Ito S, Sasaki Y, Yajima S.: Crystal structure of an IclR homologue from Microbacterium sp. strain HM58-2. Acta Crystallogr F Struct Biol Commun. 73, 16-23 (2017)
• Masuo, S., Kobayashi, Y., Oinuma, K.I., and Takaya, N.: Alternative fermentation pathway via phanyllactic acid produces cinnamic acid. Appl. Microbiol. Biotechnol. 100, 8701-8709 (2016)
• Masuo, S., Zhou, S., Kaneko, T., and Takaya, N.: Bacterial fermentation platform for producing artificial aromatic amines. Sci. Rep. 6, 25764 (2016)
• Shimizu, M., Masuo, S., Ito, E., and Takaya, N.: Thiamine synthesis regulates the fermentation mechanisms in the fungus Aspergillus nidulans. Biosci. Biotechnol. Biochem. 11, 1-8 (2016)
• Tateyama, S., Masuo, S., Suvannasara, P., Oka, Y., Miyazato, A., Yasaki, K., Teerawatananond, T., Muangsin, N., Zhou, S., Kawasaki, Y., Zhu, L., Zhou, Z., Takaya, N., and Kaneko, T.: Ultrastrong, transparent polytruxillamides derived from microbial photodimers. Macromolecules 49, 3336−3342 (2016)
• Sasaki, Y., Oguchi, H., Kobayashi, T., Kusama, S., Sugiura, R., Moriya, K., Hirata, T., Yukioka, Y., Takaya, N., Yajima, S., Ito, S., Okada, K., Osawa, K., Ikeda, H., Takano, H., Ueda, K., and Shoun, H.: Nitrogen oxide cycle regulates nitric oxide and bacterial cell signaling. Sci. Rep. 6, 22038 (2016)
• Akiyama, T., Ishige, T., Kanesaki, Y., Ito, S., Oinuma, K. I., Takaya, N., Sasaki, Y., Yajima, S.: Draft genome sequence of Microbacterium sp. strain HM58-2 that catabolites acylhydrazides. Genome Announcement 4, e00554-16. (2016)
• Kumar, A., Tateyama, S., Yasaki, K., Ali, A.M., Takaya, N., Singh, R., and Kaneko, T.: 1H-NMR and FT-IR dataset based structural investigation of poly(amic acid)s and polyimides from 4,4′-diaminostilbene. Data in Brief 7, 123-128 (2016)
• Kumar, A., Tateyama, S., Yasaki, K., Ali, M. A.., Takaya, N., Singh, R., and Kaneko, T.:Ultrahigh performance bio-based polyimides from 4,4′-diaminostilbene. Polymer, 83, 182-189 (2016)
• Nguyen, H. D., Kaneko, T., Takaya, N., Fujita, T., Ito, T.: Fermentation of aromatic lactate monomers and its polymerization to produce highly thermoresistant bioplastics.Polymer J. 48, 81-89 (2016)
• Shimizu, M., Yamamoto, T., Okabe, N., Sakai, K., Koide, E., Miyachi, Y., Kurimoto, M., Mochizuki, M., Yoshino-Yasuda, S., Mitsui, S., Ito, A., Murano, H., Takaya, N., Kato, M.: Novel 4-methyl-2-oxopentanoate reductase involved in synthesis of the Japanese sake flavor, ethyl leucate. Appl. Microbiol. Biotechnol. 100, 3137-3145 (2016)

2015年以前の論文

• Doi, Y., and Takaya, N.: A novel A3 group aconitase tolerating oxidation and nitric oxide. J. Biol. Chem. 290, 1412-1421 (2015)
• M., Sakai, K., Yamada, M., Murata, S., Itoh, E., Yamamoto, T., Sugimura, Y., Hirano, T., Takaya, N., Kobayashi, T., and Kato, M.: Novel b-1,4-mannanase belonging to a new glycoside hydrolase family in Aspergillus nidulans. J. Biol. Chem. 27914-27927 (2015)
• Oinuma, K.I., Takuwa, A., Doi, Y., and Takaya, N.: Hydrazidase; A novel amidase signature enzyme that hydrolyzes acylhydrazides. J. Bacteriol. 197, 1115-1124 (2015)
• Masuo, S., Osada, L., Zhou, S., Fujita, T., and Takaya, N.: Aspergillus oryzae pathways for converting phenylalanine into flavor volatile 2-phenylethanol. Fungal Genet. Biol. 77, 22-30 (2015)
• Kawaguchi, H., Teramura, K., Uematsu, K., Hara, Y., Hasunuma, T., Hirano, K., Sazuka, T., Kitano, H., Tsuge, Y., Kahar, P., Niimi-Nakamura, S., Oinuma, K.-I., Takaya, N., Kasuga, S., Ogino, C., and Kondo, A.: Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse. Bioresource Technol. 182, 169-178 (2015)
• Graminho, E., Takaya, N., Nakamura, A., and Hoshino, T.: Purification, biochemical characterization, and genetic cloning of the phytase produced by Burkholderia sp. strain a13. J. Gen. Appl. Micorbiol. 61, 15-23 (2015)
• Doi, Y., Shimizu, M., Fujita, T., Nakamura, A., Takizawa, N., and Takaya, N.: Achromobacter denitrificans YD35 pyruvate dehydrogenase controls NADH production to tolerate extremely high nitrite levels. Appl. Environ. Microbiol. 80, 1910-1918 (2014) [Selected as “Spotlight”]
• Toyofuku, M., Zhou, S., Sawada, I., Takaya, N., Uchiyama, H., and Nomura, N.; Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1, Environment. Microbiol. 16, 2927-2938 (2014)
• Suvannasara, P., Tateyama, S., Miyazato, A., Matsumura, K., Shimoda, T., Ito, T., Fujita, T., Yamagata, Y., Takaya, N., Kaneko, T.: Bio-based polyimides from 4-aminocinnamic acid photodimer. Macromolecules. 47, 1586-1593 (2014)
• Siriwan, W., Takaya, N., Roytrakul, S., and Chowpongpang, S.: Study of interaction between Papaya ringspot virus HC-Pro and Papaya (Carica papaya) Proteins. J. Gen. Plant Pathol. 80, 264-271 (2014)
• Sasaki, Y., Takaya, N., Morita, A., Nakamura, A., and Shoun, H.: Nitrite formation from organic nitrogen by Streptomyces antibioticus supporting bacterial cell growth and possible involvement of nitric oxide as an intermediate. Biosci. Biotechnol. Biochem. 78, 1592-1602 (2014)
• Kawaguchi, H., Uematsu, K., Ogino, C., Teramura, H., Niimi-Nakamura, S., Tsuge, Y., Hasunuma, T., Oinuma, K. Takaya, N., and Kondo, A. Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production. Biochem. Eng. J. 88, 188-194 (2014)
• Zhou, S., Narukami, T., Masuo, S., Shimizu, M., Fujita, T., Kamimura, Y., and Takaya, N.: NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nat. Chem. Biol. 9, 657-663 (2013)
• Fujita, T., Nguyen, Nieu Duc, Ito, T., Zhou, S., Osada, L., Tateyama, S., Kaneko, T., and Takaya, N.: Microbial monomers custom-synthesized to build true bio-derived aromatic polymers.Appl. Microbiol. Biothechnol. 97, 8887-8894 (2013)
• Shimizu, M., and Takaya, N.: Nudix hydrolase controls nucleotides and glycolytic mechanisms in hypoxic Aspergillus nidulans. Biosci. Biotechnol. Biochem. 77, 1888-1893 (2013)
• Sugimoto, N., Takakura, Y., Shiraki, K., Honda, S., Takaya, N., Hoshino, T., and Nakamura, A.: Directed Evolution for Thermostabilization of a Hygromycin B Phosphotransferase from Streptomyces hygroscopicus. Biosci. Biotechnol. Biochem. 77, 2234-2241 (2013)
• Siriwan, W., Roytrakul, S., Shimizu, M., Takaya, N., and Chowpongpang, S.: Proteomics of papaya ringspot virus-infected papaya leaves. Kasetsart J. (Nat. Sci.) 47, 589-602 (2013)
• Shimizu, M., Masuo, S., Fujita, T., Doi, Y., Kamimura, Y., Takaya, N.: Hydrolase controls cellular nicotinamide adenine dinucleotide, sirtuin and secondary metabolites. Mol. Cell. Biol. 32, 3743-3755 (2012)
• Shimizu, T., Takaya, N., Nakamura, A.: An L-glucose catabolic pathway in Paracoccus sp. 43P, J. Biol. Chem. 287, 40448-40456 (2012)
• Taniyama, K., Sasaki, Y., Toyofuku, M., Nomura., N., Itoh, H., Hoshino, T., and Takaya, N.: Group X aldehyde dehydrogenases of Pseudomonas aeruginosa PAO1 degrade hydrazones. J. Bacteriol.194, 1447-1456 (2012)
• Zhou, S., Narukami, T., Nameki, M., Ozawa, T., Kamimura,Y., Hoshino, T., and Takaya, N.: Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Appl. Environ. Microbiol. 78, 103-109 (2012)
• Terabayashi, Y., Shimizu, M., Kitazume, T., Masuo, S., Fujii, T., and Takaya, N.: Conserved and specific responses to hypoxia in Aspergillus oryzae and Aspergillus nidulans determined by comparative transcriptomics. Appl. Microbiol. Biothechnol. 93, 305-317 (2012)
• Fujii, T., Shimizu, M., Doi, Y., Fujita, T., Ito, T., Miura, D., Wariishi, and Takaya, N.: Novel fungal phenylpyruvate reductase belongs to D-isomer-specific 2-hydroxyacid dehydrogenase family. Biochim. Biophys. Acta. 1814, 1669-1676 (2011)
• Sato, I., Shimatani, K., Fujita, K., Abe, T., Shimizu, M., Fujii, T., Hoshino, T., and Takaya, N.: Glutathione reductase/glutathione is responsible for cytotoxic elemental sulfur tolerance via polysulfide shuttle in fungi J. Biol. Chem. 286, 20283-20291 (2011)

2010年以前の論文

• Shimizu, M., Fujii, T., Masuo, S., and Takaya, N.: Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells. Appl. Environ. Microbiol. 76, 1507-1515 (2010)
• Masuo, S., Terabayashi, Y., Shimizu, M., Fujii, T., Kitazume, T., and Takaya, N.: Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia. Mol. Genet. Genomics. 284, 415- 424 (2010)
• Tashiro, Y., Ichikawa, S., Shimizu, M., Toyofuku, M., Takaya, N., Nakajima-Kambe, T., Uchiyama, H., and Nomura, N.: Variation of physiochemical properties and cell association activity of membrane vesicles with growth phase in Pseudomonas aeruginosa. Appl. Environ. Microbiol. 76, 3732-3739 (2010)
• Zhou, Z., Takaya, N., and Shoun, H: Multi-energy metabolic mechanisms of the fungus Fusarium oxysporum under lower oxygen environments. Biosci. Biotechnol. Biochem. 74, 2431-2437 (2010)
• Sato, I., Shimizu, M., Hoshino, T., and Takaya, N.: The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase. J. Biol. Chem. 284, 8042-8053 (2009)
• Doi, Y., Takaya, N., and Takizawa, N.: Novel denitrifying bacterium Ochrobactrum anthropi YD50.2 tolerates high levels of reactive nitrogen oxides. Appl. Environ. Microbiol. 75, 5186-5194 (2009)
• Shimizu, M., Fujii, T., Masuo, S., Fujita, K., and Takaya, N.: Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions. Proteomics 9, 7-19 (2009)
• Itoh, H., Suzuta, T., Hoshino, T., and Takaya, N.: Novel dehydrogenase catalyzes oxidative hydrolysis of carbon- nitrogen double bonds for hydrazone degradation. J. Biol. Chem. 283, 5790-5800 (2008)
• Kitazume, T., Yamazaki, Y., Matsuyama, S., Shoun, H., and Takaya, N.: Production of hydroxy-fatty acid derivatives from waste oil by Escherichia coli cells producing fungal cytochrome P450foxy. Appl. Microbiol. Biothechnol. 79, 981-988 (2008)
• Fujii, T., and Takaya, N.: Denitrification by the fungus Fusarium oxysporum involves NADH-nitrate reductase. Biosci. Biotechnol. Biochem. 72, 412-420 (2008)
• Nakamura, A., Takakura, Y., Sugimoto, N., Takaya, N., Shiraki, K., and Hoshino, T.: Enzymatic analysis of a thermostabilized mutant of an Escherichia coli hygromycin B phosphotransferase. Biosci. Biotechnol. Biochem. 72, 2467-2471 (2008)
• Xiang, H., Masuo, S., Hoshino, T., and Takaya, N.: Novel family of cholesterol esterases produced by actinomycetes bacteria. Biochim. Biophys. Acta, 1774, 112-120. (2007)
• Abe, T., Hoshino, T., Nakamura, A., and Takaya, N.: Anaerobic elemental sulfur reduction by fungus Fusarium oxysporum. Biosci. Biotechnol. Biochem. 71, 2402-2407 (2007)
• Toyofuku, M., Nomura, N., Fujii, T., Takaya, N., Maseda, H., Sawada, I., Nakajima, T., and Uchiyama, H.: Quorum sensing regulates denitrification in Pseudomonas aeruginosa PAO1. J. Bacteriol. 189, 4969-4972 (2007)
• Suzuki, N., Takaya, N., Hoshino, T., and Nakamura, A.: Enhancement of a s^B-dependent stress response in Bacillus subtilisby light via YtvA Photoreceptor. J. Gen. Appl. Microbiol. 53, 81-88 (2007)
• Yamazaki, H., Yamazaki, D., Takaya, N., Takagi, M., Ohta, A, and Horiuchi, H.: A chitinase gene, chiB, involved in the autolytic process in Aspergillus nidulans. Curr. Genet. 51, 89-98. (2007)
• Takaya, N., Konas, D. W., Sharma, M., and Stuehr, D. J.: Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry, 45, 12596-12609 (2006)
• Xiang, H., Takaya, N., and Hoshino, T.: Novel cholesterol esterase secreted by Streptomyces persists during aqueous long-term storage. J. Biosci. Bioeng. 101, 19-25 (2006)

2005年以前の論文

• Doi, Y., and Takaya, N.: A novel A3 group aconitase tolerating oxidation and nitric oxide. J. Biol. Chem. 290, 1412-1421 (2015)
• span style=”font-size: 18pt;”>Shimizu, M., Kaneko, Y., Ishihara, S., Mochizuki, M., Sakai, K., Yamada, M., Murata, S., Itoh, E., Yamamoto, T., Sugimura, Y., Hirano, T., Takaya, N., Kobayashi, T., and Kato, M.: Novel b-1,4-mannanase belonging to a new glycoside hydrolase family in Aspergillus nidulans. J. Biol. Chem. 27914-27927(2015)
• Oinuma, K.I., Takuwa, A., Doi, Y., and Takaya, N.: Hydrazidase; A novel amidase signature enzyme that hydrolyzes acylhydrazides. J. Bacteriol. 197, 1115-1124 (2015)
• Masuo, S., Osada, L., Zhou, S., Fujita, T., and Takaya, N.: Aspergillus oryzae pathways for converting phenylalanine into flavor volatile 2-phenylethanol. Fungal Genet. Biol. 77, 22-30 (2015)
• Kawaguchi, H., Teramura, K., Uematsu, K., Hara, Y., Hasunuma, T., Hirano, K., Sazuka, T., Kitano, H., Tsuge, Y., Kahar, P., Niimi-Nakamura, S., Oinuma, K.-I., Takaya, N., Kasuga, S., Ogino, C., and Kondo, A.: Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse. Bioresource Technol. 182, 169-178 (2015)
• Graminho, E., Takaya, N., Nakamura, A., and Hoshino, T.: Purification, biochemical characterization, and genetic cloning of the phytase produced by Burkholderia sp. strain a13. J. Gen. Appl. Micorbiol. 61, 15-23 (2015)
• Doi, Y., Shimizu, M., Fujita, T., Nakamura, A., Takizawa, N., and Takaya, N.: Achromobacter denitrificans YD35 pyruvate dehydrogenase controls NADH production to tolerate extremely high nitrite levels. Appl. Environ. Microbiol. 80, 1910-1918 (2014) [Selected as “Spotlight”]
• Toyofuku, M., Zhou, S., Sawada, I., Takaya, N., Uchiyama, H., and Nomura, N.; Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1, Environment. Microbiol. 16, 2927-2938 (2014)
• Suvannasara, P., Tateyama, S., Miyazato, A., Matsumura, K., Shimoda, T., Ito, T., Fujita, T., Yamagata, Y., Takaya, N., Kaneko, T.: Bio-based polyimides from 4-aminocinnamic acid photodimer. Macromolecules. 47, 1586-1593 (2014)
• Siriwan, W., Takaya, N., Roytrakul, S., and Chowpongpang, S.: Study of interaction between Papaya ringspot virus HC-Pro and Papaya (Carica papaya) Proteins. J. Gen. Plant Pathol. 80, 264-271 (2014)
• Sasaki, Y., Takaya, N., Morita, A., Nakamura, A., and Shoun, H.: Nitrite formation from organic nitrogen by Streptomyces antibioticus supporting bacterial cell growth and possible involvement of nitric oxide as an intermediate. Biosci. Biotechnol. Biochem. 78, 1592-1602 (2014)
• Kawaguchi, H., Uematsu, K., Ogino, C., Teramura, H., Niimi-Nakamura, S., Tsuge, Y., Hasunuma, T., Oinuma, K. Takaya, N., and Kondo, A. Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production. Biochem. Eng. J. 88, 188-194 (2014)
• Zhou, S., Narukami, T., Masuo, S., Shimizu, M., Fujita, T., Kamimura, Y., and Takaya, N.: NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nat. Chem. Biol. 9, 657-663 (2013)
• Fujita, T., Nguyen, Nieu Duc, Ito, T., Zhou, S., Osada, L., Tateyama, S., Kaneko, T., and Takaya, N.: Microbial monomers custom-synthesized to build true bio-derived aromatic polymers.Appl. Microbiol. Biothechnol. 97, 8887-8894 (2013)
• Shimizu, M., and Takaya, N.: Nudix hydrolase controls nucleotides and glycolytic mechanisms in hypoxic Aspergillus nidulans. Biosci. Biotechnol. Biochem. 77, 1888-1893 (2013)
• Sugimoto, N., Takakura, Y., Shiraki, K., Honda, S., Takaya, N., Hoshino, T., and Nakamura, A.: Directed Evolution for Thermostabilization of a Hygromycin B Phosphotransferase from Streptomyces hygroscopicus. Biosci. Biotechnol. Biochem. 77, 2234-2241 (2013)
• Siriwan, W., Roytrakul, S., Shimizu, M., Takaya, N., and Chowpongpang, S.: Proteomics of papaya ringspot virus-infected papaya leaves. Kasetsart J. (Nat. Sci.) 47, 589-602 (2013)
• Shimizu, M., Masuo, S., Fujita, T., Doi, Y., Kamimura, Y., Takaya, N.: Hydrolase controls cellular nicotinamide adenine dinucleotide, sirtuin and secondary metabolites. Mol. Cell. Biol. 32, 3743-3755 (2012)
• Shimizu, T., Takaya, N., Nakamura, A.: An L-glucose catabolic pathway in Paracoccus sp. 43P, J. Biol. Chem. 287, 40448-40456 (2012)
• Taniyama, K., Sasaki, Y., Toyofuku, M., Nomura., N., Itoh, H., Hoshino, T., and Takaya, N.: Group X aldehyde dehydrogenases of Pseudomonas aeruginosa PAO1 degrade hydrazones. J. Bacteriol.194, 1447-1456 (2012)
• Zhou, S., Narukami, T., Nameki, M., Ozawa, T., Kamimura,Y., Hoshino, T., and Takaya, N.: Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Appl. Environ. Microbiol. 78, 103-109 (2012)
• Terabayashi, Y., Shimizu, M., Kitazume, T., Masuo, S., Fujii, T., and Takaya, N.: Conserved and specific responses to hypoxia in Aspergillus oryzae and Aspergillus nidulans determined by comparative transcriptomics. Appl. Microbiol. Biothechnol. 93, 305-317 (2012)
• Fujii, T., Shimizu, M., Doi, Y., Fujita, T., Ito, T., Miura, D., Wariishi, and Takaya, N.: Novel fungal phenylpyruvate reductase belongs to D-isomer-specific 2-hydroxyacid dehydrogenase family. Biochim. Biophys. Acta. 1814, 1669-1676 (2011)
• Sato, I., Shimatani, K., Fujita, K., Abe, T., Shimizu, M., Fujii, T., Hoshino, T., and Takaya, N.: Glutathione reductase/glutathione is responsible for cytotoxic elemental sulfur tolerance via polysulfide shuttle in fungi J. Biol. Chem. 286, 20283-20291 (2011)